WYNN A. VOLKERT, Ph.D.

Curator's Professor of Radiology, Chemistry, Biochemistry and NSEI
Office
Address:
143 Major Hall, DC 200.00
University of Missouri-Columbia
Columbia, MO 65212.
 
Phone: (573) 882-2557
Fax: (573) 882-6129
Email: RSI@health.missouri.edu
URL:

Education:

1963 B. S. Chemistry, St. Louis University
1968 Ph.D. Physical Chemistry, University of Missouri

Professional Experience:

2001- 2006 Interim Director, Nuclear Science and Engineering Institute,
1999 - present Director, Radiopharmaceutical Sciences Institute
Sept,2000-present

Curators Professor of Radiological Sciences, Biochemistry, Chemistry,and Nuclear Engineering, University of Missouri , Columbia , Missouri

1981-present

Professor of Radiological Sciences, Biochemistry, Chemistry, and Nuclear Engineering, University of Missouri , Columbia, Missouri
April,1999 - 2001 Senior Research Career Scientist, H.S. Truman Memorial Veterans Hospital , Columbia , MO
1988-1998 Associate Research Career Scientist, Veterans Administration Research Division, H.S. Truman Memorial Veterans Hospital, Columbia, MO
Jan-Aug, 1997 Visiting Research Professor, Division of Radiopharmacy, Paul Scherrer Institute, Villigen, Switzerland
Mar-Aug, 1981

Visiting Research Professor in Radiopharmaceutical Chemistry, George Washington University, Washington, D. C.

1976-present Doctoral and Graduate Faculty Member, University of Missouri, Columbia, Missouri,
1973-1981 Associate Professor of Radiological Sciences & Biochemistry, University of Missouri, Columbia, Missouri,
1969-1981 Associate Investigator, Dalton Research Center, University of Missouri, Columbia, Missouri
1969-1973 Assistant Professor of Radiological Sciences, University of Missouri, Columbia, Missouri
1967-1969 Research Associate in Physiology, NASA Postdoctoral Fellow University of Missouri, Columbia, Missouri

 

Book Chapter

Volkert, W.A.:  Targeted radiolabeled receptor-avid peptides.  In Molecular Imaging in       oncology, eds. M. Pomper, 2007 (In Press)

Recent Publications

Garrison, J.C., Rold, T.L, Sieckman, G.L, Figueroa, S.D., Volkert, W.A., Jurisson, S.S., Hoffman, T.J.:  In Vivo Evaluation and MicroPET/CT Imaging of a Prostate Cancer Mouse Model Using Copper-64 Bombesin Analogs:  Side by Side Comparison of the CB-TE2A and DOTA Chelation Systems.  J. Nucl. Med. (Submitted) 1/7/07

Winkelmann, C.T., Figueroa, S.D., Rold, T.L., Volkert, W.A., Hoffman, T.J.:  Microimaging Characterization of a B16-F10 Melanoma Metastasis Mouse Model. Molecular Imaging 5:105-114, 2006.

 Giblin, M.F., Sieckman, G.L., Shelton, T.D., Hoffman, T.J., Forte, L.R., Volkert, W.A.:  In vitro and In vivo Evaluation of 177Lu- and 90Y-labeled E. Coli Heat-stable Enterotoxin for Specific Targeting of Uroguanylin Receptors on Human ColonCancers.  Nucl. Med. & Biol. 33:481-488, 2006.

Johnson, C.V., Shelton, T., Smith, C.J., Ma, L., Perry, M.C., Volkert, W.A., Hoffman, T.J.:  Evaluation of Combined 177Lu-DOTA-8-AOC-BBN(7-14)NH2 GRP Receptor-Targeted Radiotherapy and Chemitherapy in PC-3 Human Prostate Tumor Cell Xenografted SCID Mice.  Cancer Biother. & Radiopharm. 21:155-166, 2006.

Giblin, M.F., Gali, H., Sieckman, G.L., Hoffman, T.J., Owen, N.K., Volkert, W.A. Forte, L.R.:  In Vitro and In Vivo Evaluation for 111In-labeled Human E. Coli Heat-Stable Enterotoxin Analogues for Specific-Targeting of Human Breast Cancers.  Breast Cancer Research & Treatment, 98(1):7-15, 2006.

Miller, W.H., Duval, P., Jurisson, S.S., Robertson, J.D., Wall, J.D., Quinn, T.P., Volkert, W.A., Neumeyer, G.M.:  Radiochemistry at the University of Missouri-Columbia:  A joint venture with chemistry, nuclear engineering, molecular biology, biochemistry, and the Missouri University Research Reactor (MURR).  J. Radioanalytical and Nucl. Chem., 263:131-136, 2005.
 
Smith, C.J., Volkert, W.A., Hoffman, T.J.:  Radiolabeled peptide Conjugates for
Targeting of the Bombesin Receptor.  Nucl. Med. Biol. 32:733-740, 2005.

Giblin, M.F., Sieckman, G.L., Owen, N.K., Hoffman, T.J., Forte, L.R., Volkert, W.A.:  Radiolabeled Escherichia coli heat-stable enterotoxin analogs for in vivo imaging of colorectal cancer.  Nucl. Inst. Meth. (B) 241:689-692, 2005.

 

Abstracts

Bottenus, B.N., Garrison, J.C., Rold, T.L, Sieckman, G.L, Figueroa, S.D., Volkert,
W.A., Jurisson, S.S., Hoffman, T.J.:  In vivo Stable Copper-64 Bombesin Analogs for
Diagnostic Imaging of Prostate and Breast Cancer, 54th Ann. Mtg. of the Society of
Nuclear Medicine, June 2-6, 2007, Washington, D.C., Submitted

Hoffman, T.J., Rold, T.L., Daibes, Figueroa, S., Sieckman, G.L., Garrison, J.C., Winkelmann, C.T., Smith, C.J., Perry, M.C., Volkert, W.A.:  The gastrin releasing peptide receptor (BB2r) as a potential target for diagnostic and therapeutic radiopharmaceuticals.  Proc. UICC World Cancer Congress, 2006, Bologna, Italy.  Int. J. Cancer, 2006

Hoffman, T.J., Figueroa, S.D., Rold, T.L., Sieckman, G.L., Winkelmann, C.T., Ma, L., Garrison J.C., and Volkert, W.A.:  Molecular and Anatomic Imaging in Tumor Targeted Radiopharmaceutical Drug Development, Proc. UICC World Cancer Congress, 2006, Bologna, Italy; Int. J. Cancer, 2006

Ma, L., Smith, C.J., Sieckman, G.L., Volkert, W.A., Hoffman, T.J.:  Structural
Characterization of DOTA-8-AOC Bombesin(7-14)NH2 Analogue Using Nuclear
Magnetic Resonance Spectroscopy.  J. Label. Compd. Radiopharm. 48:S341, 2005.

Volkert, W.A.:  Radiolabeled Bombesin Analogues for In Vivo Targeting of Human
Cancers.  Third La Jolla Conference – The Magic Bullit A Century Later, La Jolla,
CA, Feb 25-27, 2005.

Volkert, W.A.:  Radiolabeled Peptides for Diagnosis and Therapy.  SNM
Translational Applications of Molecular Imaging and Radionuclide Therapy
Symposium, Tempe, AZ, February 10, 2006.

Figueroa, S.D., Winkelmann, C., Miller, W., Rold, T., Sieckman, G., Smith, C.J., Ma, L., Garrison, J., Volkert, W.A., Hoffman, T.J.:  TLD-100 Measurement and Assessment of Internal Mouse Dosimetry During Micro-CT Analysis. Am. Assoc. Phys. Med. Ann. Mtg, San Juan, Puerto Rico, April, 2006; Med. Phys. 33:2211, 2006.

Giblin, M.F., Sieckman, G., Watkinson, L., Hoffman, T.J., Forte, L.R., Volkert,
W.A.:  Linker modifications of In-111-DOTA-labeled E. coli Heat-stable Enterotoxin
analogs.  Soc. Nucl. Med. Ann. Mtg., San Diego, CA, June 3-7, 2006, J. Nucl. Med.
47(5):508P, 2006.

Volkert, W.A.:  Radiolabeled Peptides for Diagnosis and Therapy, Molecular Imaging
And  Radionuclide Therapy Workshop, Toronto, Canada, June 17-18, 2005.

Ma, L., Smith, C.J., Sieckman, G., Rold, T., Hoffman, T.J., Volkert, W.A., Yu, P.:  Bombesin Receptor (BB2r) Targeted Fluorescence Imaging Probes.  Soc. Molecular Imaging Ann. Mtg, Waikoloa, HI, August 30-September 2, 2006.

Figueroa, S.D., Winkelmann, C., Rold, T., Garrison, J., Smith, C.J., Volkert, W.A., Hoffman, T.J.:  Micro-SPECT Quantification and Molecular Imaging of GRP Expressing Tumors.  Soc. Molecular Imaging Ann. Mtg, Waikoloa, HI, August 30-September 2, 2006.

Garrison, J., Rold, T., Sieckman, G., Figueroa, S.D., Ma, L., Bell, N., Carter, S., Volkert, W., Hoffman, T.J.:  Development of Indium-111 Bombesin Analogs for Diagnostic Imaging of Prostate Cancer.  Soc. Molecular Imaging Ann. Mtg, Waikoloa, HI, August 30-September 2, 2006.

Giblin, M., Liu, D., Watkinson, L., Forte, L., Volkert, W.A.:  In-111-DOTA-uroguanylin Analogs for In Vivo Imaging of Colon Cancers Expressing the GC-C Receptor.  Soc. Molecular Imaging Ann. Mtg, Waikoloa, HI, August 30-September 2, 2006.

Volkert, W.A.:  Designing New Radiotracers for Cancer Imaging and Therapy,
Science Frontiers:  Advances in Imaging Technology, St. Louis, MO, October 6, 2006.

Volkert, W.A.:  Innovations in Nuclear Infrastructure and Education.  MU and
Midwest Consortium.  Am. Nucl. Soc., Ann. Winter Meeting, Albuquerque, NM,
November 12-16, 2006.

Hoffman, T.J., Figueroa, S.D., Winkelmann, C.T., Garrison, J.C., Ma, L., Rold,
T.L., Sieckman, G.L., Smith, C.J., Volkert, W.A.:  Molecular and Anatomic Imaging
of Bombesin BB2 Receptor Expressing Tumor Models., 97th Ann. Mtg. of American
Association for Cancer Research, Washington, D.C. April 1-5, 2006.

Hoffman, T.J., Rold, T.L., Figueroa, S.D., Sieckman, G.L., Garrison, J.C.,
Winkelmann,  C.T., Smith, C.J., Volkert, W.A.:  The Gastrin Releasing Peptide
Receptor (BB2r) as a  Potential Target for Diagnostic and Therapeutic
Radiopharmaceuticals.  UICC World Cancer Congress 2006, Washington, D.C., April
1-5, 2006.

Figueroa, S.D., Winkelmann, C.T., Rold, T.L., Sieckman, G.L., Smith, C.J.,
Garrison, J.C., Ma, L., Volkert, W.A., Hoffman, T.J.:  "TLD-100 Measurement and
Assessment of Internal Mouse Dosimetry During Micro-CT Analysis, 48th Ann. Mtg.
of the American Association of Physicists in Medicine, Orlando, FL, July 2006.

Garrrison, J.C., Rold, T.L, Sieckman, G.L, Figueroa, S.D., Ma, L., Bell, N.R.,
Carter, S.N, Volkert, W.A., Hoffman, T.J.:  Development of Indium-111 Bombesin
Analogs for Diagnostic Imaging of Prostate Cancer, Fifth Ann. Mtg. of the Society of
Molecular Imaging, Waikoloa Village, HI, August-September 2006.

Figueroa, S.D., Winkelmann, C.T., Volkert, W.A., Hoffman, T.J.:  Performance Characteristics of an Integrated Small Animal SPECT/CT Unit.  Proceedings of the 2005 IEEE Nuclear Science/Medical Imaging Conf. San Juan, Puerto Rico, September 2005.

Ma, L, Smith, C.J., Sieckman, G.L., Volkert, W.A., Hoffman, T.J.:  Structural Characterization of DOTA-8-AOC-Bombesin(7-14)NH2 Analogue Using Nuclear Magnetic Resonance Spectroscopy.  16th International Symposium Radiopharm. Chem. Meeting, Iowa City, IA, June 20-24, 2005.

Giblin, M.F., Sieckman, G., Shelton, T.D., Hoffman, T.J., Forte, L.R., Volkert, W.A.:  Structure-function Studies of 111In-DOTa-labeled Human E. Coli Heat-stable Enterotoxin Analogs.  Soc. Nucl. Med. 52nd Annual Meeting, Toronto, Canada, June 18-22, 2005.  J. Nucl. Med. 46:143P, 2005.

Giblin, M.F., Sieckman, G.L., Shelton, T.D., Hoffman, T.J., Forte, L.R., Volkert,
W.A.: In Vitro and In Vivo Evaluation of 177Lu-labeled Human E. Coli Heat-stable
Enterotoxin for Specific Targeting of Human Colon Cancers.  J. Label. Compd.
Radiopharm. 48:S52, 2005.