FacultyInfo

Michael Lewis
Assistant Professor, Veterinary Medicine and Surgery, Radiology, Nuclear Science and Engineering Institute
Office Address:		Harry S Truman VA Hospital, 800 Hospital Drive, Columbia, MO 65201-5275
Mailing Address:		Department of Veterinary Medicine & Surgery, College of Veterinary Medicine, 379 East Campus Drive, Columbia, MO 65211
Phone:		573 814 6000 ext 3703
Fax:		(573) 814-6551
Email:		LewisMic@missouri.edu
URL:		http://muhealth.org/~rsi/LewisMR.html

Education:
1997	Ph.D.	Biological Sciences, City of Hope Graduate School of Biological Sciences
1988	M.S.	Chemistry, California Institute of Technology
1984	B.S	Chemistry, University of North Carolina, Chapel Hill
Professional Experience:
2000-Present		Assistant Professor, Department of Veterinary Medicine & Surgery, Department of Radiology and Nuclear Science and Engineering Institute
1997-2000		NIH Postdoctoral Fellow, Washington University School of Medicine
Research Interests:
Radiopharmaceutical Chemistry, Radiopharmaceutical Biology. Synthesis, development, evaluation and application of metal-based radiopharmaceuticals for diagnostic imaging and targeted radiotherapy of cancer.
Recent Publications:
Lewis, M.R., Zhang, J, Jia, F., Owen, N.K., Cutler, C.S., Embree, M.F., Schultz, J., Thedore, L.J., Ketring, A.R., Jurisson, S.S., and Axworthy, D.B. Biological comparison of 149Pm-, 166Ho-, and 177Lu-DOTA-biotin pretargeted by CC49 scFv-streptavidin fusion protein in xenograft-bearing nude mice. Nuclear Medicine and Biology. 31:213-223, 2004 Gallazzi, F., Wang, Y., Jia F., Shenoy, N., Landon, L.A., Hannink, M., Lever, S.Z., and Lewis, M.R. Synthesis of Radiometal-labeled and fluorescent cell-permeating peptide-PNA conjugates for targeting the bcl-2 proto-oncogene. Bioconjugate Chemistry. 14: in press; online, 22 Oct 2003 Wang, M., Caruano, A.L., Lewis, M.R., Meyer, L.A., VanderWaal, R.P., and Anderson, C.J. Subcellular localization of raiolabeled somatostatin analogues:implications for targeted radiotherapy of cancer. Cancer Research. 63: 6864-6869, 2003 Mathias, C.J., Lewis, M.R., Reichert, D.E., Laforestt, R., SHarp, T.L., Yang, Z.F., Waters, D.J., Snyder, P.W., Low, P.S., Welch, M.J., and Green, M.A. Preparation of 66Ga- and 68Ga-labeled Ga(III)-deferoxamine-folate as potential folate-receptor-targeted PET radiopharmaceuticals. Nuclear Medicine and Biology. 30:725-731, 2003. Lewis, M.R., and Jia, F. Antisense imaging: and miles to go before we sleep?. Journal of Cellular Biochemistry. 90: 464-472, 2003 Lewis, M.R., Wang, M., Axworthy, D.B., Theodore, L.J., Mallett, R.W., Fritzberg, A.R., Welch, M.J., and Anderson, C.J. In vivo evaluation of pretargeted 64Cu for tumor imaging and therapy. Journal of Nuclear Medicine. 44: 1284-1292, 2003 Lewis, M.R., Jia, F., Gallazzi, F., Wang, Y., Zhang, J., SHenoy, N., Lever, S.Z., and Hannink, M. Radiometal-labeled peptide-PNA conjugates for targeting bcl-2 expression: preparation, characterization, and in vitro mRNA binding. Bioconjugate Chemistry. 13: 1176-1180, 2002 Lewis, M.R., Reichert, D.E., Laforest, R., Margenau, W.H., Shefer, R.E., Klinkowstein, R.E., Hughey, B.J., and Welch, M.J., Production and purification of gallium-66 for preparation of tumor-targeting radiopharmaceuticals. Nuclear Medicine and Biology. 29: 701-706, 2002